Scientific Advisory Board

Amir Lerman, M.D.

SAB Chair and Advisor, Cardiology

Amir Lerman, MD, is Professor of Medicine, Division of Cardiovascular Diseases and Internal Medicine at the Mayo Clinic, Rochester, Minnesota. He serves as the Director of research of the Cardiac Catheterization Laboratory and is Director of the Chest Pain and Coronary Physiology Clinic, and is a Consultant for the Division of Cardiovascular Diseases, Mayo Graduate School of Medicine. Dr. Lerman graduated with honors from the Technion, Israel Institute of Technology, School of Medicine, in Haifa, Israel. Dr. Lerman is a Fellow of the American College of Cardiology and the European Society of Cardiology, as well as holding membership in such prestigious organizations as Sigma XI, The Scientific Research Society, the American College of Physicians, Minnesota Medical Association, and the Society of Cardiac Angiography and Interventions, among others. Dr. Lerman is on the editorial boards of several medical journals. Dr. Lerman has a special interest in the role of the endothelium in vascular tone with emphasis on the coronary circulation in atherosclerosis, acute coronary syndrome, plaque vulnerability, cardiovascular disease in women. His areas of interests also include the clinical approach to the patient with chest pain and non-obstructive disease; coronary physiology and coronary imaging.

David A. Sinclair, Ph.D.

Advisor, Genetics and Aging

Dr. Sinclair is a Professor in the Department of Genetics and co-Director of the Paul F. Glenn Center for the Biology of Aging at Harvard Medical School. He is best known for his work on understanding why we age and how to slow its effects. He obtained his Ph.D. in Molecular Genetics at the University of New South Wales, Sydney in 1995. He worked as a postdoctoral researcher at M.I.T. with Dr. Leonard Guarente where he co discovered a cause of aging for yeast as well as the role of Sir2 in epigenetic changes driven by genome instability. In 1999 he was recruited to Harvard Medical School where his laboratory's research has focused primarily on understanding the role of sirtuins in disease and aging, with associated interests in chromatin, energy metabolism, mitochondria, learning and memory, neurodegeneration, and cancer. He has also contributed to the understanding of how sirtuins are modulated by endogenous molecules and pharmacological agents such as resveratrol. Dr. Sinclair is co-founder of several biotechnology companies (Sirtris, Ovascience, Genocea, Cohbar, MetroBiotech, ArcBio, Liberty Biosecurity) and is on the boards of several others. He is also co-founder and co-chief editor of the journal Aging. His work is featured in five books, two documentary movies, 60 Minutes, Morgan Freeman's "Through the Wormhole" and other media. He is an inventor on 35 patents and has received more than 25 awards and honors including the CSL Prize, The Australian Commonwealth Prize, Thompson Prize, Helen Hay Whitney Postdoctoral Award, Charles Hood Fellowship, Leukemia Society Fellowship, Ludwig Scholarship, Harvard-Armenise Fellowship, American Association for Aging Research Fellowship, Nathan Shock Award from the National Institutes of Health, Ellison Medical Foundation Junior and Senior Scholar Awards, Merck Prize, Genzyme Outstanding Achievement in Biomedical Science Award, Bio-Innovator Award, David Murdock-Dole Lectureship, Fisher Honorary Lectureship, Les Lazarus Lectureship, Australian Medical Research Medal, The Frontiers in Aging and Regeneration Award, Top 100 Australian Innovators, and TIME magazine’s list of the "100 most influential people in the world".

C. Ronald Kahn, M.D.

Advisor, Diabetes

Dr. Kahn is the Mary K. Iacocca Professor of Medicine at Harvard Medical School and was formerly the President of the Joslin Diabetes Center. He also has served as Research Director of Joslin for more than 17 years. During his tenure, the Joslin Diabetes Center research program has grown from $2 million to over $25 million, with a staff of over 220 people. Dr. Kahn has received numerous honors and awards, including the highest scientific awards of the American Diabetes Association, Juvenile Diabetes Foundation, International Diabetes Federation, the American Federation of Clinical Research, and the Endocrine Society of the U.S. In 1999, Dr. Kahn received two prestigious national honors- election to membership in the National Academy of Sciences and election to the Institute of Medicine.

Frank J. Calzone, Ph.D.

Advisor, Cancer

Frank J. Calzone, Ph.D. has over 22 years of experience in the isolation and preclinical development of protein therapeutics for cancer and other diseases. He is a member of the UCLA Translational Oncology Research Laboratory (TORL) and his research specialties are tumor genomics and drug discovery. He also serves as Vice President of Discovery Research for REMD Biotherapeutics, a company focused on antibody therapies for diabetes and cancer.

Dr. Calzone gained his biotechnology expertise at Amgen. He joined the company as a research scientist in 1993 to identify novel growth factors and cytokines using genomics and transgenic mice. He is an inventor on the Amgen patent that first described osteoprotegerin. His research shifted in 2000 to antibody therapeutics targeting growth factor and cytokine receptors in cancer. He led the team that generated ganitumab, an inhibitory IGF1R antibody, and he served as scientific lead as it advanced clinically. He was a member of the Amgen Ventures SAB, and departed the company as a Scientific Executive Director in 2012.

Dr. Calzone has a long history of public service in breast cancer research and advocacy. He has been a scientific advisor to the Artemis Project of the National Breast Cancer Coalition from the beginning of the program in 2010. He serves on the DOD-CDMRP-BCRP integration panel (2007-present) which has overseen the investment of over $3 billion in breast cancer research.

Dr. Calzone received a Ph.D. in Molecular, Cellular and Developmental Biology from the University of Rochester. He performed his postdoctoral research in developmental biology at Caltech. He was an Assistant Professor (tenure track) at the University of California, Irvine in Developmental and Cell Biology (1989-1993).

Scientific Consultants

Rohit Loomba, M.D.

Consultant, NASH and Diseases of the Liver

Dr. Rohit Loomba is Professor of Medicine (with tenure) in the Division of Gastroenterology, and Adjunct Professor in the Division of Epidemiology at University of California, San Diego. He is a leading expert in translational research and innovative clinical trial design in nonalcoholic fatty liver disease (NAFLD) and steatohepatitis (NASH).

Dr. Loomba is the founding director of the UCSD NAFLD Translational Research Unit where his team is conducting cutting edge research in all aspects of NAFLD including non-invasive biomarkers, genetics, epidemiology, clinical trial design, imaging end-points, and integrated OMICs using microbiome, metabolome and lipidome. This integrated approach has led to several innovative applications such as establishment of MRI-PDFF as a non-invasive biomarker of treatment response in early phase trials in NASH, and first prospective study of MRE in patients with biopsy-proven NAFLD, and MOZART Trial being the first trial in NASH with comprehensive MRI and 2D and 3D MRE assessment paired with liver biopsies in NASH. He follows one of the largest cohort of well-characterized patients with NAFLD and applies evidence-based medicine to answer clinically relevant questions to improve management of patients with chronic liver disease.

He is the founder and principal investigator of the San Diego Integrated NAFLD Research Consortium (SINC). His research is funded by the National Institutes of Health, American Gastroenterology Association, National Science Foundation as well as several investigator initiated research projects funded by the industry. He is the Principal Investigator for adult hepatology for the NIDDK-sponsored NASH Clinical Research Network (2009-19) and is a member of the American Association for the Study of Liver Diseases.

Dr. Loomba is an elected member of the board of directors of the American Liver Foundation. He serves as the co-chair of the Research Award Panel for the American Liver Foundation. In addition, he serves on various committees of the American Association for the Study of Liver Diseases (AASLD). He is also an elected member of the steering committee of the Steatosis and Steatohepatitis Special Interest Group of the AASLD. He serves on the editorial board of several leading journals, and is the Associate Editor for Alimentary Pharmacology and Therapeutics, a leading journal in the field of Gastroenterology.

Changhan David Lee, Ph.D.

Consultant, Mitochondrial Biology

Changhan David Lee, PhD, is an Assistant Professor of Gerontology in the Davis School of Gerontology at the University of Southern California (USC) and a member of the USC Norris Comprehensive Cancer Center. He obtained his Ph.D. in genetics, molecular, and cellular biology at the USC Keck School of Medicine with Dr. Valter Longo where he discovered that fasting could selectively protect patients while sensitizing cancer cells to chemotherapy and radiotherapy. He worked with Dr. Pinchas Cohen as a postdoctoral researcher at UCLA where he discovered a novel gene encoded in the mitochondrial DNA, MOTS-c. He returned to the USC Davis School of Gerontology where, since 2014, his lab has been focused on understanding the role of MOTS-c in aging and age-related diseases with emphasis on cellular and organismal metabolism, mitochondrial biology, and genetic and epigenetic regulation, as well as the basic genetics and molecular biology of MOTS-c. His research has been supported by the Ellison Medical Foundation, SC CTSI, Zumberge Funds, and the Hanson Thorell Family. He received multiple awards including those from the Ellison Medical Foundation, USC Norris Cancer Center, and the American Association for Cancer Research (AACR).